Inflammatory Bowel Disease, Alpha-Synuclein Aggregates and Parkinson’s Disease: The InflamaSPark Protocol
نویسندگان
چکیده
The hallmark of Parkinson’s disease (PD) is the accumulation alpha-synuclein (AS) aggregates. Prior to central nervous system involvement, PD establishes itself in gut as a result complex interplay between microbiota, host’s immune/neural systems and increased intestinal permeability. Inflammatory Bowel Disease (IBD) patients present higher number AS aggregates wall an risk developing PD. By studying biopsy specimens IBD controls, this project aims further clarify pathophysiology explore potential for biomarker prodromal
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ژورنال
عنوان ژورنال: Medical Sciences Forum
سال: 2021
ISSN: ['2673-9992']
DOI: https://doi.org/10.3390/msf2021005028